作者
Michela Locci, Colin Havenar-Daughton, Elise Landais, Jennifer Wu, Mark A Kroenke, Cecilia L Arlehamn, Laura F Su, Rafael Cubas, Mark M Davis, Alessandro Sette, Elias K Haddad, Pascal Poignard, Shane Crotty
发表日期
2013/10/17
期刊
Immunity
卷号
39
期号
4
页码范围
758-769
出版商
Elsevier
简介
The vast majority of currently licensed human vaccines work on the basis of long-term protective antibody responses. It is now conceivable that an antibody-dependent HIV vaccine might be possible, given the discovery of HIV broadly neutralizing antibodies (bnAbs) in some HIV-infected individuals. However, these antibodies are difficult to develop and have characteristics indicative of a high degree of affinity maturation in germinal centers (GCs). CD4+ T follicular helper (Tfh) cells are specialized for B cell help and necessary for GCs. Therefore, the development of HIV bnAbs might depend on Tfh cells. Here, we identified in normal individuals a subpopulation of circulating memory PD-1+CXCR5+CD4+ T cells that are resting memory cells most related to bona fide GC Tfh cells by gene expression profile, cytokine profile, and functional properties. Importantly, the frequency of these cells correlated with the …
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M Locci, C Havenar-Daughton, E Landais, J Wu… - Immunity, 2013