作者
Caroline Jung, Jui T Ho, David J Torpy, Anne Rogers, Matt Doogue, John G Lewis, Raymond J Czajko, Warrick J Inder
发表日期
2011/5/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
96
期号
5
页码范围
1533-1540
出版商
Oxford University Press
简介
Context
There is a paucity of longitudinal data on plasma and urinary cortisol levels during pregnancy using modern assays. Furthermore, conflicting data exist as to the effect of the low-dose oral contraceptive pill (OCP) on cortisol.
Design, Subjects, and Measurements
We conducted a prospective longitudinal study on morning plasma cortisol (total and free), corticosteroid-binding globulin (CBG), and 24-h urinary free cortisol (UFC) levels in 20 pregnant women during the first, second, and third trimesters and 2–3 months postpartum compared with 12 subjects on low-dose OCP and 15 nonpregnant subjects not taking the OCP (control group).
Results
A progressive rise in total plasma cortisol, CBG, and 24-h UFC was demonstrated during pregnancy, peaking during the third trimester (mean 3-fold rise compared with controls). Plasma free cortisol increased 1.6 …
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C Jung, JT Ho, DJ Torpy, A Rogers, M Doogue… - The Journal of Clinical Endocrinology & Metabolism, 2011