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Therapeutic Advances in Drug Safety 4 (1)

6 http://taw. sagepub. com steady-state concentration in the systemic circulation. Importantly, the concentration gradient between the systemic circulation and the site of action is often determined by transport processes. Although drug transport is important to bioavailability and clearance, it sits more comfortably under the heading of distribution. The rate of distribution is particularly relevant to bolus dosing, but in continuous dosing, rate is best considered after extent.