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Latterly, scientists have turned into progressively curious about therapeutic herbs. A lot of Convolvulus taxa display different biologic activities. In this study, we aimed to evaluate nitric oxide (NO) inhibitive effect of Convolvulus aucheri in LPS-induced non-small cell lung cancer (NSCLC) cells, such as HCC78 and H1975 and determine its antioxidant capacity. While Griess assay was applied to determine the nitrite level as an index of NO production, β-carotene/linoleic acid test was used for the determining antioxidant effect. Cytotoxic activity of C. aucheri extract was detected by using CellTiter-Glo assay. The extract induced a bigger cytotoxic activity on H1975 cells than the HCC78 cells and decreased NO production in concentration-dependent manner. The highest inhibitory potential against NO formation was observed to be 113.06 μM nitrite at a concentration of 40 μg/mL in HCC78 cells. As for the antioxidant activity, C. aucheri showed the highest antioxidant activity of 70.89%. These data bring to mind that C. aucheri may be a useful source for exploration new anticancer compounds.