作者
DIS Batista, L Perez, RL Orfali, MC Zaniboni, LP Samorano, NV Pereira, MN Sotto, AS Ishizaki, LMS Oliveira, MN Sato, V Aoki
发表日期
2015/6
期刊
Journal of the European Academy of Dermatology and Venereology
卷号
29
期号
6
页码范围
1091-1095
简介
Background
Atopic dermatitis (AD) in adults and profile of skin barrier proteins and inflammatory cytokines.
Objective
Evaluation of the expression of skin barrier proteins such as filaggrin, claudins 1 and 4 and of circulating inflammatory cytokines (Th1/Th2/Th17) in adults with AD.
Methods
Thirty‐three adult patients with AD diagnosed according to the Hanifin & Rajkacriteria, and 25 healthy controls were enrolled in the study. AD severity was measured by Eczema Area and Severity Index (EASI). Laboratory assays included immunohistochemistry analysis of skin barrier proteins, such as filaggrin, claudins 1 and 4 and interleukin‐17 (IL‐17) from skin samples and determination of circulating cytokine levels (IL‐2, 4, 5, 6, 10, 17A, TNF and IFN‐γ) by flow cytometry (Cytometric Bead Array).
Results
We observed a reduced expression of filaggrin and claudin 1 in lesional skin of AD patients, when compared to controls …
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DIS Batista, L Perez, RL Orfali, MC Zaniboni… - Journal of the European Academy of Dermatology and …, 2015