作者
Richard K Albert, John Connett, William C Bailey, Richard Casaburi, J Allen D Cooper Jr, Gerard J Criner, Jeffrey L Curtis, Mark T Dransfield, MeiLan K Han, Stephen C Lazarus, Barry Make, Nathaniel Marchetti, Fernando J Martinez, Nancy E Madinger, Charlene McEvoy, Dennis E Niewoehner, Janos Porsasz, Connie S Price, John Reilly, Paul D Scanlon, Frank C Sciurba, Steven M Scharf, George R Washko, Prescott G Woodruff, Nicholas R Anthonisen
发表日期
2011/8/25
期刊
New England Journal of Medicine
卷号
365
期号
8
页码范围
689-698
出版商
Massachusetts Medical Society
简介
Background
Acute exacerbations adversely affect patients with chronic obstructive pulmonary disease (COPD). Macrolide antibiotics benefit patients with a variety of inflammatory airway diseases.
Methods
We performed a randomized trial to determine whether azithromycin decreased the frequency of exacerbations in participants with COPD who had an increased risk of exacerbations but no hearing impairment, resting tachycardia, or apparent risk of prolongation of the corrected QT interval.
Results
A total of 1577 subjects were screened; 1142 (72%) were randomly assigned to receive azithromycin, at a dose of 250 mg daily (570 participants), or placebo (572 participants) for 1 year in addition to their usual care. The rate of 1-year follow-up was 89% in the azithromycin group and 90% in the placebo group. The median time to the first exacerbation was 266 days (95% confidence interval [CI], 227 to 313) among …
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RK Albert, J Connett, WC Bailey, R Casaburi… - New England Journal of Medicine, 2011