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In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with a higher expression of 5-HT1A receptors, increased depression, and worse clinical response. These effects are paralleled by an heightened amygdala (Amy) reactivity to negative emotional stimuli. 5-HT1A receptors are post-synaptically expressed in corticolimbic regions. The aim of this study is to explore if rs6295 could influence Amy functional connectivity (FC) during implicit processing of fearful and angry faces and its relationship with the severity of depressive symptoms in 45 bipolar depressed patients (CC=8, CG=25, GG=12). We observed a significant interactive effect of rs6295 on left Amy–ventrolateral prefrontal cortex (VLPFC) FC during emotional processing. In GG patients, Amy–VLPFC connectivity for emotional stimuli was higher compared to C carriers. Furthermore, rs6295 …