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Melatonin has been shown to protect cells against oxidative and inflammatory damage via endocrine, paracrine and autocrine actions. Postmenopausal condition is associated with a high incidence of many features of metabolic syndrome including obesity, steatosis and liver oxidative injuries. The aim of this work was to investigate whether treatment with melatonin improves metabolic disturbances associated with oestrogen deficiency in ovariectomised (OVX) rats.

OVX and control (CON) female rats were treated with melatonin (10 mg/kg × day for 3 weeks, p.o.). Body weight gain, adiposity index, plasma biochemical parameters, liver lipid content, hepatic mitochondrial respiration, fatty acid oxidation and mitochondrial H₂O₂ generation and the activity of the most important enzymatic and non-enzymatic reactive oxygen species (ROS) scavenger systems were measured.

In OVX rats …