作者
Ana F Rodrigues, Manuel JT Carrondo, Paula M Alves, Ana S Coroadinha
发表日期
2014/12/1
来源
Trends in biotechnology
卷号
32
期号
12
页码范围
602-607
出版商
Elsevier
简介
The past decade witnessed the entry into the market of new virus-based biopharmaceuticals produced in animal cells such as oncolytic vectors, virus-like particle vaccines, and gene transfer vectors. Therefore, increased attention and investment to optimize cell culture processes towards enhanced manufacturing of these bioproducts is anticipated. Herein, we review key findings on virus–host interactions that have been explored in cell culture optimization. Approaches supporting improved productivity or quality of vector preparations are discussed, mainly focusing on medium design and genetic manipulation. This review provides an integrated outline for current and future efforts in exploring cellular targets for the optimization of cell culture manufacturing of virus-based biopharmaceuticals.
学术搜索中的文章
AF Rodrigues, MJT Carrondo, PM Alves… - Trends in biotechnology, 2014