作者
Cheng Han Ng, Wen Hui Lim, Grace En Hui Lim, Darren Jun Hao Tan, Nicholas Syn, Mark D Muthiah, Daniel Q Huang, Rohit Loomba
发表日期
2023/4/1
来源
Clinical Gastroenterology and Hepatology
卷号
21
期号
4
页码范围
931-939. e5
出版商
WB Saunders
简介
Background & Aims
Fibrosis is a key determinant of clinical outcomes in nonalcoholic fatty liver disease (NAFLD), but time-dependent risk of mortality has not been reported in previous meta-analyses. We performed an updated time-to-event meta-analysis to provide robust estimates for all-cause and liver-related mortality in biopsy-confirmed NAFLD with comparisons between fibrosis stages.
Methods
Medline and Embase databases were searched to include cohort studies reporting survival outcomes by fibrosis stage in biopsy-proven NAFLD. Survival estimates were pooled using reconstructed individual participant data. Conventional meta-analysis was conducted to pool adjusted hazard ratios (HRs) using DerSimonian and Laird random effects model.
Results
A total of 14 articles involving 17,301 patients with NAFLD were included. All-cause mortality at 1, 5, and 10 years for stage 0 to 2 fibrosis was 0.1%, 3.3 …
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CH Ng, WH Lim, GEH Lim, DJH Tan, N Syn… - Clinical Gastroenterology and Hepatology, 2023