作者
Guohua Zhu, Liling Warren, Jennifer Aponte, Amund Gulsvik, Per Bakke, International COPD Genetics Network (ICGN) Investigators, Wayne H Anderson, David A Lomas, Edwin K Silverman, Sreekumar G Pillai
发表日期
2007/7/15
期刊
American journal of respiratory and critical care medicine
卷号
176
期号
2
页码范围
167-173
出版商
American Thoracic Society
简介
Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by multiple genes and environmental factors. A region on chromosome 2q has been shown to be linked to COPD. A positional candidate gene from the chromosome 2q region SERPINE2 (Serpin peptidase inhibitor, clade E [nexin, plasminogen activator inhibitor type 1], member 2), was previously evaluated as a susceptibility gene for COPD in two association studies, but the results were contradictory.
Objectives: To identify the relationship between SERPINE2 polymorphisms and COPD-related phenotypes using family-based and case-control association studies.
Methods: In the present study, we genotyped 25 single nucleotide polymorphisms (SNPs) from SERPINE2 and analyzed qualitative and quantitative COPD phenotypes in 635 pedigrees with 1,910 individuals and an independent case-control population that …
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G Zhu, L Warren, J Aponte, A Gulsvik, P Bakke… - American journal of respiratory and critical care …, 2007