作者
Xiangyang Kong, Michael H Cho, Wayne Anderson, Harvey O Coxson, Nestor Muller, George Washko, Eric A Hoffman, Per Bakke, Amund Gulsvik, David A Lomas, Edwin K Silverman, Sreekumar G Pillai
发表日期
2011/1/1
期刊
American journal of respiratory and critical care medicine
卷号
183
期号
1
页码范围
43-49
出版商
American Thoracic Society
简介
Rationale: Chronic obstructive pulmonary disease (COPD), characterized by airflow limitation, is a disorder with high phenotypic and genetic heterogeneity. Pulmonary emphysema is a major but variable component of COPD; familial data suggest that different components of COPD, such as emphysema, may be influenced by specific genetic factors.
Objectives: To identify genetic determinants of emphysema assessed through high-resolution chest computed tomography in individuals with COPD.
Methods: We performed a genome-wide association study (GWAS) of emphysema determined from chest computed tomography scans with a total of 2,380 individuals with COPD in three independent cohorts of white individuals from (1) a cohort from Bergen, Norway, (2) the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study, and (3) the National Emphysema Treatment Trial …
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X Kong, MH Cho, W Anderson, HO Coxson, N Muller… - American journal of respiratory and critical care …, 2011