作者
Nicolas Gendron, Marie‐Agnès Dragon‐Durey, Richard Chocron, Luc Darnige, Georges Jourdi, Aurélien Philippe, Camille Chenevier‐Gobeaux, Jérôme Hadjadj, Jérôme Duchemin, Lina Khider, Nader Yatim, Guillaume Goudot, Daphné Krzisch, Benjamin Debuc, Laetitia Mauge, Françoise Levavasseur, Frédéric Pene, Jeremy Boussier, Elise Sourdeau, Julie Brichet, Nadège Ochat, Claire Goulvestre, Christophe Peronino, Tali‐Anne Szwebel, Franck Pages, Pascale Gaussem, Charles‐Marc Samama, Cherifa Cheurfa, Benjamin Planquette, Olivier Sanchez, Jean‐Luc Diehl, Tristan Mirault, Michaela Fontenay, Benjamin Terrier, David M Smadja
发表日期
2021/11
期刊
Arthritis & Rheumatology
卷号
73
期号
11
页码范围
1976-1985
简介
Objective
The clinical relevance of antiphospholipid antibodies (aPLs) in COVID‐19 is controversial. This study was undertaken to investigate the prevalence and prognostic value of conventional and nonconventional aPLs in patients with COVID‐19.
Methods
This was a multicenter, prospective observational study in a French cohort of patients hospitalized with suspected COVID‐19.
Results
Two hundred forty‐nine patients were hospitalized with suspected COVID‐19, in whom COVID‐19 was confirmed in 154 and not confirmed in 95. We found a significant increase in lupus anticoagulant (LAC) positivity among patients with COVID‐19 compared to patients without COVID‐19 (60.9% versus 23.7%; P < 0.001), while prevalence of conventional aPLs (IgG and IgM anti–β2‐glycoprotein I and IgG and IgM anticardiolipin isotypes) and nonconventional aPLs (IgA isotype of anticardiolipin, IgA isotype of anti‐β2 …
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