作者
Aurélien Philippe, Richard Chocron, Nicolas Gendron, Olivier Bory, Agathe Beauvais, Nicolas Peron, Lina Khider, Coralie L Guerin, Guillaume Goudot, Françoise Levasseur, Christophe Peronino, Jerome Duchemin, Julie Brichet, Elise Sourdeau, Florence Desvard, Sébastien Bertil, Frédéric Pene, Cherifa Cheurfa, Tali-Anne Szwebel, Benjamin Planquette, Nadia Rivet, Georges Jourdi, Caroline Hauw-Berlemont, Bertrand Hermann, Pascale Gaussem, Tristan Mirault, Benjamin Terrier, Olivier Sanchez, Jean-Luc Diehl, Michaela Fontenay, David M Smadja
发表日期
2021/8/1
期刊
Angiogenesis
页码范围
1-13
出版商
Springer Netherlands
简介
Background
Coronavirus disease 2019 (COVID-19) is a respiratory disease associated with endotheliitis and microthrombosis.
Objectives
To correlate endothelial dysfunction to in-hospital mortality in a bi-centric cohort of COVID-19 adult patients.
Methods
Consecutive ambulatory and hospitalized patients with laboratory-confirmed COVID-19 were enrolled. A panel of endothelial biomarkers and von Willebrand factor (VWF) multimers were measured in each patient ≤ 48 h following admission.
Results
Study enrolled 208 COVID-19 patients of whom 23 were mild outpatients and 189 patients hospitalized after admission. Most of endothelial biomarkers tested were found increased in the 89 critical patients transferred to intensive care unit. However, only von Willebrand factor antigen (VWF:Ag) scaled …
学术搜索中的文章
A Philippe, R Chocron, N Gendron, O Bory, A Beauvais… - Angiogenesis, 2021