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Physical activity results in a series of proinflammatory reactions and innate immune responses, which occur postexercise. This is followed by antiinflammatory reactions that are critical for regeneration and healing. The severity of inflammation following exercise depends on the type, duration, and intensity of the exercise bout, as well as the training status of the individual. Interventions designed to reduce the inflammatory response following exercise may, in fact, be detrimental to adaptation, though they may positively impact performance and competition with short turnaround times. Although acute inflammation is critical for recovery, chronic inflammation—even low-grade systemic and tissue-specific simmering inflammation—appears to be a mechanism associated with the aging process and is related to many chronic diseases. It appears that regular, sustained physical activity, including endurance and resistance …