作者
Girish N Nadkarni, Geneviève Galarneau, Stephen B Ellis, Rajiv Nadukuru, Jinglan Zhang, Stuart A Scott, Claudia Schurmann, Rongling Li, Laura J Rasmussen-Torvik, Abel N Kho, M Geoffrey Hayes, Jennifer A Pacheco, Teri A Manolio, Rex L Chisholm, Dan M Roden, Joshua C Denny, Eimear E Kenny, Erwin P Bottinger
发表日期
2017/3/28
期刊
Journal of the American College of Cardiology
卷号
69
期号
12
页码范围
1564-1574
出版商
American College of Cardiology Foundation
简介
Background
African Americans (AA) are disproportionately affected by hypertension-related health disparities. Apolipoprotein L1 (APOL1) risk variants are associated with kidney disease in hypertensive AAs.
Objectives
This study assessed the APOL1 risk alleles’ association with blood pressure traits in AAs.
Methods
The discovery cohort included 5,204 AA participants from Mount Sinai’s BioMe biobank. Replication cohorts included additional BioMe (n = 1,623), Vanderbilt BioVU (n = 1,809), and Northwestern NUgene (n = 567) AA biobank participants. Single nucleotide polymorphisms determining APOL1 G1 and G2 risk alleles were genotyped in BioMe and imputed in BioVU/NUgene participants. APOL1 risk alleles’ association with blood pressure–related traits was tested in the discovery cohort, a meta-analysis of replication cohorts, and a combined meta-analysis under recessive and additive models after …
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GN Nadkarni, G Galarneau, SB Ellis, R Nadukuru… - Journal of the American College of Cardiology, 2017