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PET with ¹⁸F-FDG may be useful for quantifying neutrophilic activation. We previously demonstrated that pulmonary neutrophil sequestration could be detected during acute lung injury (ALI), even without migration into the alveolar compartment. Using the influx constant K_i as the method to quantify lung ¹⁸F-FDG uptake, we also showed that K_i correlated positively with in vitro assays of ³H-deoxyglucose (³H-DG) uptake in cells harvested via bronchoalveolar lavage. In the present study, we have reanalyzed data from that study to determine if simpler nonkinetic methods of quantifying the pulmonary uptake of ¹⁸F-FDG could be as powerful as calculating K_i. ¹⁸F-FDG uptake was quantified as K_i, calculated by 3-compartmental model analysis (used as the gold standard) and Patlak graphical analysis, with and without normalization for initial volume of tracer distribution; the standardized uptake value; and …