作者
Andrea Cercek, Walid K Chatila, Rona Yaeger, Henry Walch, Gustavo Dos Santos Fernandes, Asha Krishnan, Lerie Palmaira, Anna Maio, Yelena Kemel, Preethi Srinivasan, Chaitanya Bandlamudi, Erin Salo-Mullen, Prince R Tejada, Kimeisha Belanfanti, Jesse Galle, Vijai Joseph, Neil Segal, Anna Varghese, Diane Reidy-Lagunes, Jinru Shia, Efsevia Vakiani, Sebastian Mondaca, Robin Mendelsohn, Melissa A Lumish, Felix Steinruecke, Nancy Kemeny, Louise Connell, Karuna Ganesh, Arnold Markowitz, Garrett Nash, Jose Guillem, J Joshua Smith, Phillip B Paty, Liying Zhang, Diana Mandelker, Ozge Birsoy, Mark Robson, Kenneth Offit, Barry Taylor, Michael Berger, David Solit, Martin Weiser, Leonard B Saltz, Julio Garcia Aguilar, Nikolaus Schultz, Luis A Diaz Jr, Zsofia K Stadler
发表日期
2021/12/1
期刊
JNCI: Journal of the National Cancer Institute
卷号
113
期号
12
页码范围
1683-1692
出版商
Oxford University Press
简介
Background
The causative factors for the recent increase in early-onset colorectal cancer (EO-CRC) incidence are unknown. We sought to determine if early-onset disease is clinically or genomically distinct from average-onset colorectal cancer (AO-CRC).
Methods
Clinical, histopathologic, and genomic characteristics of EO-CRC patients (2014-2019), divided into age 35 years and younger and 36-49 years at diagnosis, were compared with AO-CRC (50 years and older). Patients with mismatch repair deficient tumors, CRC-related hereditary syndromes, and inflammatory bowel disease were excluded from all but the germline analysis. All statistical tests were 2-sided.
Results
In total, 759 patients with EO-CRC (35 years, n = 151; 36-49 years, n = 608) and AO-CRC (n = 687) were included. Left-sided tumors (35 years and younger = 80.8%; 36 …
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A Cercek, WK Chatila, R Yaeger, H Walch… - JNCI: Journal of the National Cancer Institute, 2021