作者
Yan Yang, Xiaoyue Wang, Xiao Lin, Lingxiao Xie, Ryan Ivone, Jie Shen, Gensheng Yang
发表日期
2020/6/15
期刊
International journal of pharmaceutics
卷号
583
页码范围
119360
出版商
Elsevier
简介
Extruded 3D printing is emerging as an attractive fabrication technology in the field of personalized oral medicines. The objective of this study was to develop a tunable extruded 3D printing platform based on thermo-sensitive gelatin pastes to meet the needs of achieving different drug release characteristics with flexible dosing and design. The printability and mechanisms of extrusion and deposition of the gelatin pastes were systematically studied. Ibuprofen and diclofenac sodium were used as model drugs for immediate- and sustained-release formulations, respectively. Following the optimization of formulation and process parameters, ibuprofen immediate-release formulations with different designs, and reservoir-type diclofenac sodium sustained-release formulations were printed. Target drug release patterns were successfully obtained for both model drugs. Rheological studies revealed that additives such as …
学术搜索中的文章
Y Yang, X Wang, X Lin, L Xie, R Ivone, J Shen, G Yang - International journal of pharmaceutics, 2020