作者
SS An, Tony R Bai, JHT Bates, JL Black, RH Brown, V Brusasco, P Chitano, L Deng, M Dowell, DH Eidelman, B Fabry, NJ Fairbank, LE Ford, JJ Fredberg, WT Gerthoffer, SH Gilbert, R Gosens, SJ Gunst, AJ Halayko, RH Ingram, CG Irvin, AL James, LJ Janssen, GG King, DA Knight, AM Lauzon, OJ Lakser, MS Ludwig, KR Lutchen, GN Maksym, JG Martin, T Mauad, BE McParland, SM Mijailovich, HW Mitchell, RW Mitchell, W Mitzner, TM Murphy, PD Pare, R Pellegrino, MJ Sanderson, RR Schellenberg, CY Seow, PSP Silveira, PG Smith, J Solway, NL Stephens, PJ Sterk, AG Stewart, DD Tang, RS Tepper, T Tran, L Wang
发表日期
2007/5/1
来源
European Respiratory Journal
卷号
29
期号
5
页码范围
834-860
出版商
European Respiratory Society
简介
Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma.
As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the pathophysiology of asthma. However, the precise role of ASM in the series of events leading to asthmatic symptoms is not clear. It is not certain whether, in asthma, there is a change in the intrinsic properties of ASM, a change in the structure and mechanical properties of the noncontractile components of the airway wall, or a change in the interdependence of the airway wall with the surrounding lung parenchyma. All these potential changes could result from acute or chronic airway inflammation and associated tissue repair and remodelling.
Anti-inflammatory therapy, however, does not “cure” asthma, and airway hyperresponsiveness can persist in asthmatics, even in the absence of …
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SS An, TR Bai, JHT Bates, JL Black, RH Brown… - European Respiratory Journal, 2007