作者
Bernice Lo, Ussama M Abdel-Motal
发表日期
2017/12/1
来源
Current opinion in immunology
卷号
49
页码范围
14-19
出版商
Elsevier Current Trends
简介
Highlights
- CTLA-4 is crucial for quantitative regulation of immune homeostasis and tolerance.
- LRBA plays a role in maintaining an intracellular pool of CTLA-4 in Tregs and activated T cells.
- Heterozygous CTLA4 or biallelic LRBA mutations can lead to autoimmune disease in humans but not in mice.
- CTLA-4 blockade therapy can unleash underlying antitumor or autoimmune responses.
- The microbiota play a critical role in modulating immune activation thresholds regulated by CTLA-4.
CTLA-4 is a crucial negative regulator of immune responses. Absence of CTLA-4 in mice causes autoimmunity and lethal multiorgan lymphocytic infiltration and tissue destruction. Recently, heterozygous CTLA4 or biallelic LRBA mutations leading to functional CTLA-4 deficiency and autoimmunity have been discovered. LRBA was identified as a novel regulator of steady-state CTLA-4 protein levels in Tregs and activated T cells. CTLA-4 …
学术搜索中的文章
B Lo, UM Abdel-Motal - Current opinion in immunology, 2017