作者
Hanru Wang, Caitlin L Brook, Alexandra L Whittaker, Andrew Lawrence, Roger Yazbeck, Gordon S Howarth
发表日期
2013/8/1
期刊
Scandinavian Journal of Gastroenterology
卷号
48
期号
8
页码范围
959-968
出版商
Taylor & Francis
简介
Background
Mucositis is a debilitating intestinal side effect of chemotherapeutic regimens. Probiotics have been considered a possible preventative treatment for mucositis. Streptococcus thermophilus TH-4 (TH-4), a newly identified probiotic, has been shown to partially alleviate mucositis induced by administration of the antimetabolite chemotherapy drug, methotrexate in rats; likely mediated through a mechanism of folate production. However, its effects against other classes of chemotherapy drug have yet to be determined. Aims
The authors investigated the effects of TH-4 in a rat model of mucositis induced by the anthracycline chemotherapy drug, doxorubicin. Methods
Gastrointestinal damage was induced in female Dark Agouti rats (148.3 ± 1.5 g) by intraperitoneal injection of doxorubicin (20 mg/kg). Animals recieved a daily oral gavage of TH-4 at 109 cfu/ml or skim milk (vehicle) from days 0 to 8. At day 6 …学术搜索中的文章
H Wang, CL Brook, AL Whittaker, A Lawrence… - Scandinavian Journal of Gastroenterology, 2013