作者
Benjamin Y Winer, Elham Shirvani-Dastgerdi, Yaron Bram, Julie Sellau, Benjamin E Low, Heath Johnson, Tiffany Huang, Gabriela Hrebikova, Brigitte Heller, Yael Sharon, Katja Giersch, Sherif Gerges, Kathleen Seneca, Mihai-Alexandru Pais, Angela S Frankel, Luis Chiriboga, John Cullen, Ronald G Nahass, Marc Lutgehetmann, Jared E Toettcher, Michael V Wiles, Robert E Schwartz, Alexander Ploss
发表日期
2018/6/27
期刊
Science translational medicine
卷号
10
期号
447
页码范围
eaap9328
出版商
American Association for the Advancement of Science
简介
Chronic delta hepatitis, caused by hepatitis delta virus (HDV), is the most severe form of viral hepatitis, affecting at least 20 million hepatitis B virus (HBV)–infected patients worldwide. HDV/HBV co- or superinfections are major drivers for hepatocarcinogenesis. Antiviral treatments exist only for HBV and can only suppress but not cure infection. Development of more effective therapies has been impeded by the scarcity of suitable small-animal models. We created a transgenic (tg) mouse model for HDV expressing the functional receptor for HBV and HDV, the human sodium taurocholate cotransporting peptide NTCP. Both HBV and HDV entered hepatocytes in these mice in a glycoprotein-dependent manner, but one or more postentry blocks prevented HBV replication. In contrast, HDV persistently infected hNTCP tg mice coexpressing the HBV envelope, consistent with HDV dependency on the HBV surface antigen …
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BY Winer, E Shirvani-Dastgerdi, Y Bram, J Sellau… - Science translational medicine, 2018