作者
Anne-Christine Bay-Jensen, Suzi Hoegh-Madsen, Erik Dam, Kim Henriksen, Bodil Cecillie Sondergaard, Philippe Pastoureau, Per Qvist, Morten A Karsdal
发表日期
2010/2
来源
Rheumatology international
卷号
30
页码范围
435-442
出版商
Springer-Verlag
简介
Osteoarthritis (OA) is a disease of the entire joint. Different treatment strategies for OA have been proposed and tested clinically without the desired efficacy. One reason for the scarcity of current chondroprotective agents may be the insufficient understanding of the patho-physiology of the joint and whether the joint damage is reversible or irreversible. In this review, we compile emerging data on cellular and pathological aspects of OA, and ask whether these data could give clue to when cartilage degradation is reversible and whether a point-of-no-return exists. We highlight different stages of OA, and speculate whether different intervention strategies (e.g. DMOAD vs. SMOADs) may only be efficacious at distinct stages of OA.
学术搜索中的文章
AC Bay-Jensen, S Hoegh-Madsen, E Dam… - Rheumatology international, 2010