作者
Maulik D Majmudar, Jeongsoo Yoo, Edmund J Keliher, Jessica J Truelove, Yoshiko Iwamoto, Brena Sena, Partha Dutta, Anna Borodovsky, Kevin Fitzgerald, Marcelo F Di Carli, Peter Libby, Daniel G Anderson, Filip K Swirski, Ralph Weissleder, Matthias Nahrendorf
发表日期
2013/3/1
期刊
Circulation research
卷号
112
期号
5
页码范围
755-761
出版商
Lippincott Williams & Wilkins
简介
Rationale:
Myeloid cell content in atherosclerotic plaques associates with rupture and thrombosis. Thus, imaging of lesional monocytes and macrophages could serve as a biomarker of disease progression and therapeutic intervention.
Objective:
To noninvasively assess plaque inflammation with dextran nanoparticle (DNP)-facilitated hybrid positron emission tomography/magnetic resonance imaging (PET/MRI).
Methods and Results:
Using clinically approved building blocks, we systematically developed 13-nm polymeric nanoparticles consisting of cross-linked short chain dextrans, which were modified with desferoxamine for zirconium-89 radiolabeling (89Zr-DNP) and a near-infrared fluorochrome (VT680) for microscopic and cellular validation. Flow cytometry of cells isolated from excised aortas showed DNP uptake predominantly in monocytes and macrophages (76.7%) and lower signal originating from other …
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MD Majmudar, J Yoo, EJ Keliher, JJ Truelove… - Circulation research, 2013