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Wireless sensor network (WSN) is becoming ubiquitous in several applications including remote health care, fire tracking, integrated system health monitoring (ISHM), industrial automation, and space, to name a few. Their small size and pervasive computing characteristics enabled intelligence to be implemented deep in network-centered applications and systems. In particular, space applications are using WSNs to ensure the overall missions’ success from asset management to crew heath monitoring. For instance, space crew health performance can be tracked down using telemedicine by taking advantage of sensor local processing and networking capabilities. The sensors can monitor the profile of key vital signs of astronauts and predict whether the astronaut is at the risk to be injured. Implementation of WSN-based systems that provides end-to-end solutions requires innovative approaches at different levels of …