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Azadirachtin was tested for its effects against First PP and second instars larvae of mosquito Culex pipiens pipiens (Diptera: Culicidae), laboratory reared larvae were exposed to 0.125; 0.250; 0.500 and 0.750 mg/L of azadirachtin in laboratory of biology animal application, biology Department, university of Badji Mokhtar, Annaba, Algeria. Larvicidal assays were conducted according to standard World Health Organization (WHO). The results have been exploited according to classic statistical methods. A linear correlation was revealed between concentration and larval mortality. At first stage, larval mortality increased from 45.83% at 0.125 mg/L to 94.44% at concentration 0.750 mg/L of Azadirachtin in direct effect. The lethal concentration LCR16R, LCR50R and LCR90R in direct effect was measured as 0.056; 0.166 and 0.663 mg/L respectively. Cumulate mortality increased from 54.28% to 95.71% at 0.125 mg/L and …