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This paper reports on the use of a microfluidic dielectric sensor, termed ClotChip, for monitoring the fibrin polymerization effects on whole blood coagulation. The ClotChip sensor readout captures the temporal variation in the normalized real part of the blood dielectric permittivity at 1MHz as it undergoes coagulation. A new readout parameter, S _max , is identified in the ClotChip readout curve, which represents the maximum permittivity slope after a permittivity peak is reached. Experiments based on ex vivo treatment of whole blood samples with H-Gly-Pro-Arg-Pro-OH (GPRP) - a fibrin-polymerization inhibitor - demonstrate that S _max decreases with increasing GPRP concentrations corresponding to higher levels of fibrin inhibition. Furthermore, S _max is shown to exhibit a strong positive correlation (Pearson's r = 0.883, p <; 0.001, n = 12) with the α-angle readout parameter of rotational thromboelastometry - a …