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Purpose:: Age-related macular degeneration (AMD) is the leading cause of blindness. The neovascular AMD can be subdivided into predominantly classic (PC) and minimally classic/occult (MC-O) choroidal neovascularisation (CNV). Several studies have suggested that complement factor F (CFH) Y402H polymorphisms are associated with classic CNV as compared with occult CNV suggesting there are pathophysiological differences of the 2 types of CNV. To investigate the association of polymorphisms in CFH (rs1061170), Factor B/C2 (rs 9332739, rs547154, rs4151667, rs641153), LOC387715 (rs10490924), and HTRA1 (rs11200638) with CNV phenotype.

Methods:: PCR amplification of genomic DNA extracted from peripheral blood from 185 patients of a Caucasian population with neovascular AMD. CFH, Factor B/C2, LOC387715 and HTRA1 were analysed via Taqman PCR techniques. Chi-Square test for …