作者
Yoav Ben-Shlomo, Melissa Spears, Chris Boustred, Margaret May, Simon G Anderson, Emelia J Benjamin, Pierre Boutouyrie, James Cameron, Chen-Huan Chen, J Kennedy Cruickshank, Shih-Jen Hwang, Edward G Lakatta, Stephane Laurent, João Maldonado, Gary F Mitchell, Samer S Najjar, Anne B Newman, Mitsuru Ohishi, Bruno Pannier, Telmo Pereira, Ramachandran S Vasan, Tomoki Shokawa, Kim Sutton-Tyrell, Francis Verbeke, Kang-Ling Wang, David J Webb, Tine Willum Hansen, Sophia Zoungas, Carmel M McEniery, John R Cockcroft, Ian B Wilkinson
发表日期
2014/2/25
来源
Journal of the American College of Cardiology
卷号
63
期号
7
页码范围
636-646
出版商
American College of Cardiology Foundation
简介
Objectives
The goal of this study was to determine whether aortic pulse wave velocity (aPWV) improves prediction of cardiovascular disease (CVD) events beyond conventional risk factors.
Background
Several studies have shown that aPWV may be a useful risk factor for predicting CVD, but they have been underpowered to examine whether this is true for different subgroups.
Methods
We undertook a systematic review and obtained individual participant data from 16 studies. Study-specific associations of aPWV with CVD outcomes were determined using Cox proportional hazard models and random effect models to estimate pooled effects.
Results
Of 17,635 participants, a total of 1,785 (10%) had a CVD event. The pooled age- and sex-adjusted hazard ratios (HRs) per 1-SD change in loge aPWV were 1.35 (95% confidence interval [CI]: 1.22 to 1.50; p < 0.001) for coronary heart disease, 1.54 (95% CI: 1.34 to 1.78; p < …
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Y Ben-Shlomo, M Spears, C Boustred, M May… - Journal of the American College of Cardiology, 2014