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Ageing is associated with a progressive decline in cognitive function, which occurs according to heterogeneous trajectories, dependent on multiple physiological and environmental components. To tackle this major challenge, we designed a project to test the effect of a tailored physical exercise intervention program in the cognitive function of a Portuguese elderly cohort, included in the AGA@4life project. The exercise program included aerobic and strength components, prescribed in a personalized approach according to the AGA@4life model, and implemented under direct control of two experienced professionals. The 33 included elderly participants were divided into two groups (intervention group –IG – and control group – CG) according to their willingness to participate in the physical training program. Cognitive function was evaluated with the Cambridge Neuropsychological Test Automated Battery (CANTAB …