作者
C Dessinioti, AC Geller, AJ Stratigos
发表日期
2022/11
来源
Journal of the European Academy of Dermatology and Venereology
卷号
36
期号
11
页码范围
1927-1936
简介
Cutaneous melanoma may have an adjacent nevus remnant on histological examination in 30% of cases (nevus‐associated melanoma, NAM), while it may appear de novo, without a precursor lesion, in the remaining 70% of cases. Nevus‐associated melanoma and the concept of acquired melanocytic nevi serving as precursors of melanoma has long been considered as a controversial topic. This controversy is, in part, due to their overall low rate of transformation to melanoma and scarce data on the natural history of progression. Another matter of debate regarded the possibility that the reported differences in NAM vs. de novo melanoma were due to an underestimation of NAM in thicker lesions due to obliteration of the nevus component by the tumour. During the last few years, several evidence has accumulated in order to address these controversies. In this review, we present a comprehensive synthesis of the …
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C Dessinioti, AC Geller, AJ Stratigos - Journal of the European Academy of Dermatology and …, 2022