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Multi-sector efforts to address the structural drivers of health inequities faced by racial and ethnic minority communities in the USA often ignore the potential of action by for-profit businesses, perhaps due to skepticism about the role of business in such efforts. However, given the need to harness diverse forms of capital to address structural harms, and recent calls to identify oft-ignored systemic pathways to health, we examined the role of business – specifically small, locally-owned businesses – in promoting community health and well-being. This study explored the role of small, locally owned businesses in community health, and local understandings of the value of such action, in the context of Roxbury, Massachusetts, a historically Black community with a substantial Latinx population. We conducted 20 semi-structured interviews between June and November 2021 with small business owners and staff, as well as …