作者
Eman Al-Sayed, Haidy E Michel, Mohamed Abdelrazik Khattab, Mohamed El-Shazly, Abdel Nasser Singab
发表日期
2020/1
期刊
Planta medica
卷号
86
期号
01
页码范围
32-44
出版商
Georg Thieme Verlag KG
简介
Gastric ulcer is a major health problem. Current treatment options of gastric ulcer, including antagonists of histamine H2 receptor and inhibitors of the proton pump, do not cure gastric ulcers, but only provide temporary relief of symptoms and can be associated with severe side effects. The lack of effective and safe medications for this global health problem urges for the discovery of novel classes of compounds with potent activity and an acceptable safety profile. Ethanol-induced ulceration in rats was used to evaluate the gastroprotective activity of casuarinin, an ellagitannin isolated from Melaleuca leucadendra. Casuarinin (25, 50, and 100 mg/kg) reduced the ulcer area by 45, 78, and 99%, respectively, compared with the ulcer group. Casuarinin (100 mg/kg) increased mucin content by 1.8-fold and reduced acidity by 42%. At the same dose, it also increased the levels of reduced glutathione by 194%, catalase by …
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E Al-Sayed, HE Michel, MA Khattab, M El-Shazly… - Planta medica, 2020