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A new series of hydrazone and bishydrazone derivatives was synthesized starting from adipic dihydrazide, oxalyl dihydrazide, 4-hydroxybenzhydrazide, 2-furancarboxylic acid hydrazide, acetohydrazide, 4-pyridinecarboxylic acid hydrazide, and isatin. The chemical structures were confirmed by means of ¹H-NMR, UV, and IR spectral data and elemental analysis. The synthesized compounds were evaluated in vitro as antimicrobial agents against representative strains of Gram-positive (clinical strains of Staphylococcus saprophyticus, Bacillus cereus, Enterococcus faesium), Gram-negative bacteria (clinical strains of Klebsiella pneumonia, Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa, Shigella dysenteriae, Salmonella typhi), and antifungal agent against Candida albicans (clinical isolated) by the minimal inhibitory concentration (MIC) method. MIC was defined as the lowest concentration …