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Improving the supply of O₂ and the circulation lifetime of photosensitizers for photodynamic therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein, by taking advantage of the significant gas-adsorption capability of metal-organic frameworks (MOFs), a biomimetic O₂-evolving photodynamic therapy (PDT) nanoplatform with long circulating properties was fabricated. Zirconium (IV)-based MOF (UiO-66) was used as a vehicle for O₂ storing, then conjugated with indocyanine green (ICG) by coordination reaction, and further coated with red blood cell (RBC) membranes. Upon 808 nm laser irradiation, the initial singlet oxygen (¹O₂) generated by ICG would decompose RBC membranes. At the same time, The photothermal property of ICG could facilitate the burst release of O₂ from UiO-66. Subsequently, the generated O₂ could significantly improve the PDT effects on hypoxic tumor …