作者
Horng H Chen, Kevin J Anstrom, Michael M Givertz, Lynne W Stevenson, Marc J Semigran, Steven R Goldsmith, Bradley A Bart, David A Bull, Josef Stehlik, Martin M LeWinter, Marvin A Konstam, Gordon S Huggins, Jean L Rouleau, Eileen O'Meara, WH Wilson Tang, Randall C Starling, Javed Butler, Anita Deswal, G Michael Felker, Christopher M O'Connor, Raphael E Bonita, Kenneth B Margulies, Thomas P Cappola, Elizabeth O Ofili, Douglas L Mann, Víctor G Dávila-Román, Steven E McNulty, Barry A Borlaug, Eric J Velazquez, Kerry L Lee, Monica R Shah, Adrian F Hernandez, Eugene Braunwald, Margaret M Redfield, NHLBI Heart Failure Clinical Research Network
发表日期
2013/12/18
期刊
Jama
卷号
310
期号
23
页码范围
2533-2543
出版商
American Medical Association
简介
Importance
Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously tested.
Objective
To test the 2 independent hypotheses that, compared with placebo, addition of low-dose dopamine (2 μg/kg/min) or low-dose nesiritide (0.005 μg/kg/min without bolus) to diuretic therapy will enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction.
Design, Setting, and Participants
Multicenter, double-blind, placebo-controlled clinical trial (Renal Optimization Strategies Evaluation [ROSE]) of 360 hospitalized patients with acute heart failure and renal dysfunction (estimated glomerular filtration rate of 15-60 mL/min/1.73 m2), randomized within 24 hours of admission. Enrollment occurred from September 2010 to …
学术搜索中的文章
HH Chen, KJ Anstrom, MM Givertz, LW Stevenson… - Jama, 2013