作者
Paola Conti, Lucia Tamborini, Andrea Pinto, Laura Sola, Roberta Ettari, Ciro Mercurio, Carlo De Micheli
发表日期
2010/9/1
期刊
European journal of medicinal chemistry
卷号
45
期号
9
页码范围
4331-4338
出版商
Elsevier Masson
简介
A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check its participation in the coordinating process.
学术搜索中的文章
P Conti, L Tamborini, A Pinto, L Sola, R Ettari… - European journal of medicinal chemistry, 2010