作者
modENCODE Consortium, Sushmita Roy, Jason Ernst, Peter V Kharchenko, Pouya Kheradpour, Nicolas Negre, Matthew L Eaton, Jane M Landolin, Christopher A Bristow, Lijia Ma, Michael F Lin, Stefan Washietl, Bradley I Arshinoff, Ferhat Ay, Patrick E Meyer, Nicolas Robine, Nicole L Washington, Luisa Di Stefano, Eugene Berezikov, Christopher D Brown, Rogerio Candeias, Joseph W Carlson, Adrian Carr, Irwin Jungreis, Daniel Marbach, Rachel Sealfon, Michael Y Tolstorukov, Sebastian Will, Artyom A Alekseyenko, Carlo Artieri, Benjamin W Booth, Angela N Brooks, Qi Dai, Carrie A Davis, Michael O Duff, Xin Feng, Andrey A Gorchakov, Tingting Gu, Jorja G Henikoff, Philipp Kapranov, Renhua Li, Heather K MacAlpine, John Malone, Aki Minoda, Jared Nordman, Katsutomo Okamura, Marc Perry, Sara K Powell, Nicole C Riddle, Akiko Sakai, Anastasia Samsonova, Jeremy E Sandler, Yuri B Schwartz, Noa Sher, Rebecca Spokony, David Sturgill, Marijke van Baren, Kenneth H Wan, Li Yang, Charles Yu, Elise Feingold, Peter Good, Mark Guyer, Rebecca Lowdon, Kami Ahmad, Justen Andrews, Bonnie Berger, Steven E Brenner, Michael R Brent, Lucy Cherbas, Sarah CR Elgin, Thomas R Gingeras, Robert Grossman, Roger A Hoskins, Thomas C Kaufman, William Kent, Mitzi I Kuroda, Terry Orr-Weaver, Norbert Perrimon, Vincenzo Pirrotta, James W Posakony, Bing Ren, Steven Russell, Peter Cherbas, Brenton R Graveley, Suzanna Lewis, Gos Micklem, Brian Oliver, Peter J Park, Susan E Celniker, Steven Henikoff, Gary H Karpen, Eric C Lai, David M MacAlpine, Lincoln D Stein, Kevin P White, Manolis Kellis, David Acevedo, Richard Auburn, Galt Barber, Hugo J Bellen, Eric P Bishop, Terri D Bryson, Aurelien Chateigner, Jia Chen, Hiram Clawson, Charles LG Comstock, Sergio Contrino, Leyna C DeNapoli, Queying Ding, Alex Dobin, Marc H Domanus, Jorg Drenkow, Sandrine Dudoit, Jackie Dumais, Thomas Eng, Delphine Fagegaltier, Sarah E Gadel, Srinka Ghosh, Francois Guillier, David Hanley, Gregory J Hannon, Kasper D Hansen, Elizabeth Heinz, Angie S Hinrichs, Martin Hirst, Sonali Jha, Lichun Jiang, Youngsook L Jung, Helena Kashevsky, Cameron D Kennedy, Ellen T Kephart, Laura Langton, Ok-Kyung Lee, Sharon Li, Zirong Li, Wei Lin, Daniela Linder-Basso, Paul Lloyd, Rachel Lyne, Sarah E Marchetti, Marco Marra, Nicolas R Mattiuzzo, Sheldon McKay, Folker Meyer, David Miller, Steven W Miller, Richard A Moore, Carolyn A Morrison, Joseph A Prinz
发表日期
2010/12/24
期刊
Science
卷号
330
期号
6012
页码范围
1787-1797
出版商
American Association for the Advancement of Science
简介
To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and tissue-specific regulators, and enables gene-expression prediction. Our results provide a foundation for directed experimental and …
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