作者
Pierre Simeone, Guillaume Auzias, Julien Lefevre, Sylvain Takerkart, Olivier Coulon, Blandine Lesimple, Grégory Torkomian, Valentine Battisti, Alice Jacquens, David Couret, Lionel Naccache, Eleonore Bayen, Nicolas Bruder, Vincent Perlbarg, Louis Puybasset, Lionel Velly
发表日期
2021/10/28
期刊
Annals of physical and rehabilitation medicine
页码范围
101599
简介
Background
Traumatic brain injury (TBI) lesions are known to evolve over time, but the duration and consequences of cerebral remodelling are unclear. Degenerative mechanisms occurring in the chronic phase after TBI could constitute “tertiary” lesions related to the neurological outcome.
Objective
The objective of this prospective study of severe TBI was to longitudinally evaluate the volume of white and grey matter structures and white matter integrity with 2 time-point multimodal MRI.
Methods
Longitudinal MRI follow-up was obtained for 11 healthy controls (HCs) and 22 individuals with TBI (mean [SD] 60 [15] months after injury) along with neuropsychological assessments. TBI individuals were classified in the “favourable” recovery group (Glasgow Outcome Scale Extended [GOSE] 6–8) and “unfavourable” recovery group (GOSE 3–5) at 5 years. Variation in brain volumes (3D T1-weighted image) and white matter …
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P Simeone, G Auzias, J Lefevre, S Takerkart, O Coulon… - Annals of physical and rehabilitation medicine, 2022