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Bitter melon (Momordica charantia L.) has been widely used as an traditional medicine treatment for diabetic patients in Asia. In vitro and animal studies suggested its hypoglycemic activity, but limited human studies are available to support its use.

This study was conducted to assess the efficacy and safety of three doses of bitter melon compared with metformin.

This is a 4-week, multicenter, randomized, double-blind, active-control trial. Patients were randomized into 4 groups to receive bitter melon 500mg/day, 1000mg/day, and 2000mg/day or metformin 1000mg/day. All patients were followed for 4 weeks.

There was a significant decline in fructosamine at week 4 of the metformin group (−16.8; 95% CI, −31.2, −2.4μmol/L) and the bitter melon 2000mg/day group (−10.2; 95% CI, −19.1, −1.3μmol/L). Bitter melon 500 …