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This article aims to study the heat transfer performances and the degree of thermodynamic irreversibility of two types of hybrid nanofluids, namely MWCNT + Fe₃O₄/water and ND + Fe₃O₄/water used in a flattened tube. The three-dimensional numerical analysis was performed for different working conditions as: Reynolds number (within the range 250–2000), volume concentration of hybrid nanoparticles (0–0.3%) and inlet temperatures (from 313 K to 333 K). The numerical results show that the use of hybrid nanofluids in flattened tubes enhances the heat transfer at all studied Reynolds numbers. The MWCNT + Fe₃O₄/water hybrid nanofluids exhibited higher enhancement in heat transfer compared to ND + Fe₃O₄/water hybrid nanofluids. In additions, the results indicate that the increase in volume concentration of hybrid nanoparticles leads to the decrease of the total entropy generation of MWCNT …