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Systematic reviews agree that knee osteoarthritis (OA) is related to occupational activities, but have not quantified the overall risks.

Systematic review of observational studies of knee OA and occupation. Job titles, elite sport, heavy work, kneeling, and other activities were included. Relative risk estimate and 95% confidence interval (CI) compared to sedentary work were retrieved or calculated for meta-analysis. Publication bias was examined with Egger tests and heterogeneity was determined with I² values and Q tests. Subgroup analysis was performed to examine causes of heterogeneity. A random effects model was performed to combine the data.

Studies of knee OA (n=51), persistent knee pain (n=12) and knee OA progression (n=3) were retrieved. Occupational risks for knee OA were examined in a total of 526,343 subjects in 8 cohort/prospective/longitudinal studies, 25 …