作者
Przemyslaw Rys, Sebastian Borys, Jerzy Hohendorff, Aleksandra Zapala, Przemyslaw Witek, Magdalena Monica, Claudia Frankfurter, Agnieszka Ludwig-Slomczynska, Beata Kiec-Wilk, Maciej T Malecki
发表日期
2020/4
来源
Endocrine
卷号
68
页码范围
44-55
出版商
Springer US
简介
Purpose
Negative-pressure wound therapy (NPWT) is an adjunct modality in diabetic foot ulcerations (DFUs). Randomized controlled trials (RCTs) have shown its advantage over standard approaches; however, data from observational studies remain scarce.We performed a systematic review of observational non-RCTs evaluating NPWT efficacy and safety in patients with DFU.
Methods
Electronic databases were searched for observational studies involving NPWT. The results of single-arm studies were presented as percentages of patients with the outcome of interest. A meta-analysis of comparative studies provided point estimates of outcomes. Continuous outcomes were reported as either weighted or standardized mean differences and dichotomous data as relative risks (RR).
Results
The search identified 16 relevant observational studies, 12 single-arm, and 4 comparative, reporting on a total of 18,449 …
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P Rys, S Borys, J Hohendorff, A Zapala, P Witek… - Endocrine, 2020