作者
Hany S Abed, JR Fulcher, Michael J Kilborn, Anthony C Keech
发表日期
2016/8
来源
Internal Medicine Journal
卷号
46
期号
8
页码范围
875-883
出版商
John Wiley & Sons Australia, Ltd
简介
Inappropriate sinus tachycardia (IST) is an incompletely understood condition, characterised by an elevation in heart rate (HR) accompanied by wide ranging symptoms in the absence of an underlying physiological stimulus. The condition often takes a chronic course with significant adverse effects on quality of life. Currently, there is no effective treatment for IST. Beta‐blockers, generally considered the cornerstone of treatment, are often ineffective and poorly tolerated. Ivabradine is a novel sinus node If ‘funny current’ inhibitor, which reduces the HR. It has been approved for the treatment of beta‐blocker refractory chronic systolic heart failure and chronic stable angina but more recently has shown promise in the treatment of IST. This review provides an overview of IST prevalence and mechanisms followed by an examination of the evidence for the role and efficacy of ivabradine in the treatment of IST.
引用总数
2017201820192020202120222023202423332322
学术搜索中的文章
HS Abed, JR Fulcher, MJ Kilborn, AC Keech - Internal Medicine Journal, 2016