作者
Karin A Slot, Jan Kastelijn, Anne Bachelot, Paul A Kelly, Nadine Binart, Katja J Teerds
发表日期
2006/3/1
期刊
Reproduction
卷号
131
期号
3
页码范围
525-532
出版商
Society for Reproduction and Fertility
简介
GH influences female fertility. The goal of the present study was to obtain more insight into the effect of loss of GH signalling, as observed in humans suffering from Laron syndrome, on ovarian function. Therefore, serial paraffin sections of ovaries of untreated and IGF-I-treated female GH receptor knock-out (GHR/GHBP-KO) mice were examined to determine the follicular reserve and the percentage of follicular atresia in each ovary. Our observations demonstrate that the amount of primordial follicles was significantly elevated in GHR/GHBP-KO mice, while the numbers of primary, preantral and antral follicles were lower compared with wild-type values. The reduced number of healthy growing follicles in GHR/GHBP-KO mice was accompanied by a significant increase in the percentage of atretic follicles. IGF-I treatment of GHR/GHBP-KO mice for 14 days resulted in a reduced number of primordial follicles, an …
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KA Slot, J Kastelijn, A Bachelot, PA Kelly, N Binart… - Reproduction, 2006