作者
Shuyan Wei, Erika Gonzalez Rodriguez, Ronald Chang, John B Holcomb, Lillian S Kao, Charles E Wade, Charles E Wade, Deborah J del Junco, Erin E Fox, Nena Matijevic, Jeanette Podbielski, Angela M Beeler, Barbara C Tilley, Sarah Baraniuk, Hongjian Zhu, Joshua Nixon, Roann Seay, Savitri N Appana, Hui Yang, Michael O Gonzalez, Lisa Baer, Yao-Wei Willa Wang, Brittany S Hula, Elena Espino, An Nguyen, Nicholas Pawelczyk, Kisha D Arora-Nutall, Rishika Sharma, Jessica C Cardenas, Elaheh Rahbar, Tyrone Burnett Jr, David Clark, Gerald van Belle, Susanne May, Brian Leroux, David Hoyt, Judy Powell, Kellie Sheehan, Alan Hubbard, Adam P Arkin, John R Hess, Jeanne Callum, Bryan A Cotton, Laura Vincent, Timothy Welch, Tiffany Poole, Evan G Pivalizza, Sam D Gumbert, Yu Bai, James J McCarthy, Amy Noland, Rhonda Hobbs, Eileen M Bulger, Patricia Klotz, Lindsay Cattin, Keir J Warner, Angela Wilson, David Boman, Nathan White, Andreas Grabinsky, Jennifer A Daniel-Johnson, Mitchell Jay Cohen, Rachael A Callcut, Mary Nelson, Brittney Redick, Amanda Conroy, Marc P Steurer, Preston C Maxim, Eberhard Fiebig, Joanne Moore, Eireen Mallari, Peter Muskat, Jay A Johannigman, Bryce RH Robinson, Richard D Branson, Dina Gomaa, Christopher Barczak, Suzanne Bennett, Patricia M Carey, Christopher N Miller, Helen Hancock, Carolina Rodriguez, Kenji Inaba, Jay G Zhu, Monica D Wong, Michael Menchine, Kelly Katzberg, Sean O Henderson, Rodney McKeever, Ira A Shulman, Janice M Nelson, Christopher W Tuma, Cheryl Y Matsushita, Thomas M Scalea, Deborah M Stein, Cynthia K Shaffer, Christine Wade, Anthony V Herrera, Seeta Kallam, Sarah E Wade, Samuel M Galvagno Jr, Magali J Fontaine, Janice M Hunt, Rhonda K Cooke, Timothy C Fabian, Jordan A Weinberg, Martin A Croce, Suzanne Wilson, Stephanie Panzer-Baggett, Lynda Waddle-Smith, Sherri Flax, Karen J Brasel, Pamela Walsh, David Milia, Allia Nelson, Olga Kaslow, Tom P Aufderheide, Jerome L Gottschall, Erica Carpenter, Terence O'Keeffe, Laurel L Rokowski, Kurt R Denninghoff, Daniel T Redford, Deborah J Novak, Susan Knoll, Jeffrey D Kerby, Jean-Francois Pittet, Patrick L Bosarge, Albert T Pierce, Carolyn R Williams, Shannon W Stephens, Henry E Wang, Marisa B Marques, Martin A Schreiber, Jennifer M Watters, Samantha J Underwood, Tahnee Groat, Craig Newgard, Matthias Merkel, Richard M Scanlan, Beth Miller, Sandro Rizoli, Homer Tien, Barto Nascimento, Sandy Trpcic, Skeeta Sobrian-Couroux, Marciano Reis, Adic Pérez, Susan E Belo, Lisa Merkley
发表日期
2018/12/1
期刊
Journal of the American College of Surgeons
卷号
227
期号
6
页码范围
587-595
出版商
No longer published by Elsevier
简介
Background
Endotheliopathy of trauma is characterized by breakdown of the endothelial glycocalyx. Elevated biomarkers of endotheliopathy, such as serum syndecan-1 (Synd-1) ≥ 40 ng/mL, have been associated with increased need for transfusions, complications, and mortality. We hypothesized that severely injured trauma patients who exhibit elevated Synd-1 levels shortly after admission have an increased likelihood of developing sepsis.
Study Design
We analyzed a subset of patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial who survived at least 72 hours after hospital admission, and we determined elevated Synd-1 levels (≥ 40 ng/mL) 4 hours after hospital arrival. Sepsis was defined a priori as meeting systemic inflammatory response criteria and having a known or suspected infection. Univariate analysis was performed to identify variables associated with …
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S Wei, EG Rodriguez, R Chang, JB Holcomb, LS Kao… - Journal of the American College of Surgeons, 2018