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There is an ongoing desire to define "value" in clinical research. ESMO-MCBS is a commonly used framework, endorsed by ESMO and used by several governments in their health technology assessments in various settings. Such value frameworks have not been validated for assessing benefit derived from radiotherapy (RT). We herein assess the applicability of the ESMO-MCBS in radiation oncology, using breast cancer as a test-case.

We reviewed the supportive literature used by the ASTRO Evidence-Based Guideline on Radiation Therapy for the Whole Breast for adjuvant whole breast Radiation Therapy. We delineated a pool of "core" (112 studies) and "supplemental" articles (additional 65 studies). Among these, we identified a subset of 15 randomized trials, 1 systematic review and 1 big data study. The goals of our exercise were (1) to evaluate the "scorability" of data …