作者
Lyndah Chow, William Wheat, Dominique Ramirez, Renata Impastato, Steven Dow
发表日期
2024/1/26
期刊
Scientific Reports
卷号
14
期号
1
页码范围
2207
出版商
Nature Publishing Group UK
简介
The canine spontaneous cancer model is increasingly utilized to evaluate new combined cancer immunotherapy approaches. While the major leukocyte subsets and phenotypes are closely related in dogs and humans, the functionality of T cells and antigen presenting cells in the two species has not been previously compared in detail. Such information would be important in interpreting immune response data and evaluating the potential toxicities of new cancer immunotherapies in dogs. To address this question, we used in vitro assays to compare the transcriptomic, cytokine, and proliferative responses of activated canine and human T cells, and also compared responses in activated macrophages. Transcriptomic analysis following T cell activation revealed shared expression of 515 significantly upregulated genes and 360 significantly downregulated immune genes. Pathway analysis identified 33 immune …
学术搜索中的文章
L Chow, W Wheat, D Ramirez, R Impastato, S Dow - Scientific Reports, 2024