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The aim of this research was to investigate the coexposure of nanoparticles of titanium dioxide (TiO₂) and copper oxide (CuO) on the alterations of the gill, intestine, kidney, and liver tissues of carps (Cyprinus carpio). In this study, carps (length 23 ± 1.5 cm; weight 13 ± 1.3 g) were divided into six groups of 15 each and exposed to 2.5 and 5.0 mg L⁻¹ of CuO nanoparticles (NPs), 10.0 mg L⁻¹ of TiO₂ NPs, and 2.5 and 5.0 mg L⁻¹ of CuO NPs + 10.0 mg L⁻¹ of TiO₂ NP mixture. Fish were sampled for histopathological studies after hematoxylin-eosin staining. Results indicated that the more kinds of histopathology anomalies observed with CuO NP and TiO₂ NP mixture were broadly of the same type as CuO NPs and TiO₂ NPs alone, but the severity or incidence of injuries of gill, intestine, liver, and kidney of carps in the mixture of CuO NPs + TiO₂ NPs was higher than that of each NP alone. Moreover …